Sho Iketani, PhD

  • Assistant Professor of Medical Sciences (in Medicine)

On the web

Profile Headshot

Profile Navigation

Overview

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine)

Languages

  • Japanese

Gender

  • Male

Credentials & Experience

Education & Training

  • BA, 2015 Biological Sciences/Economics, Cornell University
  • MS, 2016 Biology, ETH Zürich
  • PhD, 2022 Microbiology and Immunology, Columbia University

Honors & Awards

  • 2022 Dean’s Award for Excellence in Research, Columbia University
  • 2022 Richard C. Parker Graduate Student Award, Columbia University

Research

Selected Publications

  1. Duan Y*, Zhou H*, Liu X*, Iketani S*, Lin M*, Zhang X, Bian Q, Wang H, Sun H, Hong SJ, Culbertson B, Mohri H, Luck MI, Yang X, Yang K, Sabo Y, Chavez A, Goff S, Rao Z, Ho DD, Yang H. (2023). Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature 622(7982): 376-382.
  2. Wang Q*, Iketani S*, Li Z*, Liu L*, Guo Y*, Huang Y, Bowen AD, Liu M, Wang M, Yu J, Valdez R, Lauring A, Sheng Z, Wang HH, Gordon A, Liu L, Ho DD. (2023). Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell 186(2): 279-286.
  3. Iketani S*, Mohri H*, Culbertson B*, Hong SJ*, Duan Y, Luck MI, Annavajhala MK, Guo Y, Sheng Z, Uhlemann AC, Goff SP, Sabo Y, Yang H, Chavez A, Ho DD. (2023). Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Nature 613(7944): 558-564.
  4. Iketani S*, Hong SJ*, Sheng J*, Bahari F*, Culbertson B, Atanaki FF, Aditham AK, Kratz AF, Luck MI, Tian R, Goff SP, Montazeri H, Sabo Y, Ho DD, Chavez A. (2022). Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Cell Host & Microbe 30(10): 1354-1362.
  5. Liu L*, Iketani S*, Guo Y*, Casner RG*, Reddem ER*, Nair MS*, Yu J*, Chan JFW*, Wang M, Cerutti G, Li Z, Castagna CD, Corredor L, Chu H, Yuan S, Poon VKM, Chan CCS, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD. (2022). An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science Translational Medicine 14(646): eabn6859.
  6. Iketani S*, Liu L*, Guo Y*, Liu L*, Chan JFW*, Huang Y, Wang M, Luo Y, Yu J, Chu H, Chik KKH, Yuen TTT, Yin MT, Sobieszczyk ME, Huang Y, Yuen KY, Wang HH, Sheng Z, Ho DD. (2022). Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages. Nature 604(7906): 553-556.
  7. Liu L*, Iketani S*, Guo Y*, Chan JFW*, Wang M*, Liu L*, Luo Y, Chu H, Huang Y, Nair MS, Yu J, Chik KKH, Yuen TTT, Yoon C, To KKW, Chen H, Yin MT, Sobieszczyk ME, Huang Y, Wang HH, Sheng Z, Yuen KY, Ho DD. (2022). Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2. Nature 602(7898): 676-681.
    Iketani S, Forouhar F, Liu H, Hong SJ, Lin F-Y, Nair MS, Zask A, Huang Y, Xing L, Stockwell BR, Chavez A, Ho DD. (2021). Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nature Communications 12(1): 2016.

For a complete list of publications, please visit PubMed.gov