Guo Lab

The Guo Lab focuses on unraveling the complexities of humoral immune responses to infectious diseases and advancing our understanding of vaccination mechanisms. Leveraging state-of-the-art bioinformatics and interdisciplinary approaches, we aim to develop novel therapeutics for combating viruses with pandemic potential, explore the dynamics of virus evolution and host responses, and uncover the underlying mechanisms of disease processes. Our integrated technological platforms and collaborative research efforts are dedicated to translating scientific discoveries into effective health solutions.

Areas of Interest

Broad and Potent Neutralizing Antibodies

We are dedicated to identifying and characterizing broad and potent neutralizing antibodies that can offer protection against a wide range of viral pathogens. This research is crucial for developing more effective vaccines and therapeutic agents that can confer long-lasting immunity across diverse populations and viral strains. Our research currently targets sarbecoviruses, influenza A viruses, and henipaviruses, which are critical due to their potential for widespread impact and severe disease outcomes.

Trajectory of Viral Evolution

Our lab studies viral evolution to understand how viruses adapt in response to host immune defenses. Over the past four years, we have focused on tracing the evolution of SARS-CoV-2 and its immune evasion properties, providing valuable insights that have guided clinical decisions on the use of antibodies and vaccines against emerging variants. Moving forward, we will apply our expertise to study the evolution of other viruses with pandemic potential. This knowledge is crucial for predicting future viral threats and developing strategies to contain and control outbreaks before they escalate to pandemic levels.

Molecular Mechanisms for Viruses-Related Disease

We explore the molecular mechanisms behind virus-related diseases, focusing on how viruses hijack host cellular machinery to replicate and spread within the host. Viruses such as HIV, HSV, CMV, EBV, and Varicella Zoster Virus can establish latency in cells or organs within the human body. Understanding these processes is crucial for developing targeted therapies that disrupt viral replication and alleviate disease symptoms.